Cambridge MA, USA, APRIL 16, 2025 – BlueRock Therapeutics LP, a clinical-stage cell therapy company and wholly owned subsidiary of Bayer AG, today announced the publication of the 18-month data from its Phase 1 exPDite clinical trial for bemdaneprocel in the journal Nature. “The […]
Single-cell RNA sequencing (scRNA-seq) allows for an unbiased assessment of cellular phenotypes by enabling the extraction of transcriptomic data. An important question in downstream analysis is how to evaluate biological similarities and differences between samples in high dimensional space. This becomes especially complex when […]
Mucopolysaccharidoses are inherited metabolic disorders caused by the deficiency in lysosomal enzymes required to break down glycosaminoglycans. Accumulation of glycosaminoglycans leads to progressive, systemic degenerative disease. The central nervous system is particularly affected, resulting in developmental delays, neurological regression, and early mortality. Current treatments […]
Dhahri et al. describe practical methods for the scaled generation of mature hPSC-CMs and provide the first evidence that the transplantation of more mature cardiomyocytes yields better outcomes in vivo. Read more.
Funakoshi et al establish a differentiation strategy that promotes the specification, proliferation and maturation of compact ventricular cardiomyocytes from human pluripotent stem cells (hPSCs). Read more.
Kim et al present a protocol that is the basis for clinical-grade mDA neuron production and preclinical safety and efficacy studies. Read more.
Piao et al generated midbrain dopamine neurons from human embryonic stem cells and manufactured large-scale cryopreserved dopamine progenitors for clinical use. There were no adverse effects attributable to the grafted cells, no obvious distribution outside the brain, and no cell overgrowth or tumor formation, […]
Hartman and Laflamme provide a perspective on these studies and describe studies to directly reconstitute cardiomyocytes by ex vivo expansion from pluripotent stem cells. Read more.
Lee et al demonstrate the recapitulation of cardiomyocyte developmental pathways in producing and characterizing PSC derived cardiomyocytes and their authenticity when compared to adult tissue. Read more.
Gornalusse et al demonstrate that master cell banks of pluripotent stem cells can be gene edited to ablate HLA receptors and avoid T cell recognition. In addition, these banks are engineered to express a recombinant receptor to prevent innate cell clearance. This escape from […]
